File Name: alcohol and cardiovascular disease .zip
Back to Health A to Z. Cardiovascular disease CVD is a general term for conditions affecting the heart or blood vessels.
Recent Developments in Alcoholism pp Cite as. The ingestion of one or two alcoholic drinks can affect heart rate, blood pressure, cardiac output, myocardial contractility, and regional blood flow. These actions generally are not clinically important.
In the presence of cardiovascular disease, however, even such small quantities of alcohol might result in transient unfavorable hemodynamic changes. Moreover, alcohol abuse can produce cardiac arrhythmias, hypertension, cardiomyopathy, stroke, and even sudden death. In contrast, moderate alcohol use produces changes that have an overall favorable effect on atherosclerotic-related vascular diseases.
Because cardiovascular disease due to atherosclerosis is the leading cause of death in Western society, this desirable effect of alcohol use outweighs its detrimental actions, resulting in favorable findings in population studies.
This is a preview of subscription content, log in to check access. Google Scholar. N Engl J Med —, Ann Intern Med —, PubMed Google Scholar. Gaziano JM, Buring JE, Breslow JL, et al: Moderate alcohol intake, increased of high-density lipoprotein and its subfractions and decreased risk of myocardial infarction.
Mechanisms and Management. New York, Plenum Medical, , pp — Nakano J, Moore SE: Effect of different alcohols on the contractile force of the isolated guinea pig myocardium. Eur J Pharmacol —, Am J Physiol —, Richards IS, Kulkarni A, Brooks SM, et al: A moderate concentration of ethanol alters cellular membrane potentials and decreases contractile force of human fetal heart. Dev Pharmacol Ther —56, Am J Cardiol —, Altura BM, Altura B: Microvascular and vascular smooth muscle actions of ethanol, acetaldehyde and acetate.
Fed Proc —, Am HeartJ —, CrossRef Google Scholar. Circulation —, Cherrick GR, Leevy GM: The effect of ethanol metabolism on levels of oxidized and reduced nicotinamide-adenine dinucleotide in liver, kidney and heart. Biochim Biophys Acta —37, Am Heart J —, Science —, Lang LG: Nonoxidative ethanol metabolism: Formation of fatty acid ethyl esters by cholesterol esterase. Circ Res —, J Clin Invest —, Res Commun Chem PatholPharmacol —, Segel LB: Mitochondrial respiration after cardiac perfusion with ethanol or acetaldehyde.
Alcohol Clin Exp Res —, J Mol Cell Cardiol —, Alcohol —, Siddiq T, Richardson PJ, Mitchell WD, et al: Ethanol-induced inhibition of ventricular protein synthesis in vivo and the possible role of acetaldehyde. Cell Biochem Funct —54, Mongo KG, Vassort G: Inhibition by alcohols, halothane and chloroform of the Ca current in single frog ventricular cells. Guarnieri T, Lakatta EG: Mechanism of myocardial contractile depression by clinical concentrations of ethanol.
Biochem Pharmacol —, J Surg Res —, Biochem Med Metab Biol —, Biochem Pharmacol —32, Puszkin, Rubin E: Adenosine diphosphate effect on contractility of human muscle actomyosin: Inhibition by ethanol and acetaldehyde. Am J Physiol G—G, Psychosom Med —, Hatake K, Wakabayashi I, Hishida S: Mechanism of inhibitory action of ethanol on endothelium-dependent relaxation in rat aorta. Br J Pharmacol —, Ann EmergMed —, Proc Soc Exp Biol Med —, Br J Pharmacol Chemother —, JAMA —10, Stroke —, J Stud Alcohol —, Am J Psychiatry —, J Cardiovasc Pharmacol —, J Pharmacol Exp Ther —, Mendoza LC, Hellberg K, Rickart A, et al: The effect of intravenous ethyl alcohol on the coronary circulation and myocardial contractility of the human and canine heart.
J Clin Pharmacol —, Cardiovasc Res —, Abel FL: Direct effects of ethanol on myocardial performance and coronary resistance. J Pharmacol Exp Ther —33, Friedman HS: Acute effects of ethanol on myocardial blood flow in the nonischemic and ischemic heart. Am J Cardiol —67, Ahlawat S, Siwach SB, Jadish: Indirect assessment of acute effects of ethyl alcohol on coronary circulation in patients with chronic stable angina.
Int J Cardiol —, Rossinen J, Paratanen J, Koskinen P, et al: Acute heavy alcohol intake increases silent myocardial ischemia in patients with stable angina pectoris. Heart —, Am J Surg —23, Arch Surg —, Brigden W, Robinson J: Alcoholic heart disease. Br Med J —, Friedman HS, Cirillo N, Schiano F, et al: Vasodilatory state of decompensated cirrhosis: Relation to hepatic dysfunction, ascites and vasoactive substances.
Mathews E, Gardin JM, Henry W, et al: Echocardiographic abnormalities in chronic alcoholics with and without overt congestive heart failure. Am J Cardiol —, Google Scholar. Alexander CS: Idiopathic heart disease. Am J Med —, Alexander CS: Electron microscopic observations in alcoholic heart disease. Br Heart J —, Hepatology —, Am J Physiol G52—G57, Munzo DF, Caramelo C, Santos JC, et al: Systemic and splanchnic hemodynamic disturbances in conscious rats with experimental liver cirrhosis without ascites.
Am J Physiol H—H, Kravetz D, Aarderiu M, Bosch J, et al: Hyperglucagonemia and hyperkinetic circulation after portocaval shunt in the rat. Am J Physiol C—G, Lancet —, Direct evidence from intraneural recordings. Gastroenterology —99,
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Marmot and E. Marmot , E.
Arch Intern Med. The authors have no relevant financial interest in this article. Compared with individuals who rarely or never drank alcoholic beverages, those who reported monthly, weekly, and daily alcohol consumption, respectively, had multivariate adjusted relative risks RRs for CVD mortality of 0. In the same groups, RRs for total mortality were respectively 0. Among men with a systolic blood pressure of mm Hg or higher or a diastolic blood pressure of 90 mm Hg or higher, the RRs for CVD mortality were, respectively, 1. A recently published American Heart Association Science advisory states that"patients who are hypertensive should avoid alcoholic beverages.
Cardiovascular disease CVD is a class of diseases that involve the heart or blood vessels. The underlying mechanisms vary depending on the disease.
Your email address will not be published. Required fields are marked *