File Name: genomics type 2 diabetes and obesity .zip
Type 2 diabetes T2D is a progressive disease whereby there is often deterioration in glucose control despite escalation in treatment. There is significant heterogeneity to this progression of glycemia after onset of diabetes, yet the factors that influence glycemic progression are not well understood. Given the tremendous burden of diabetes in the Chinese population, and limited knowledge on factors that influence glycemia, we aim to identify the clinical and genetic predictors for glycemic progression in Chinese patients with T2D. During a median follow-up period of 8.
Diabetes is a complex condition. Several factors must come together for you to develop type 2 diabetes. For example, obesity and a sedentary lifestyle play a role. Several gene mutations have been linked to the development of type 2 diabetes. These gene mutations can interact with the environment and each other to further increase your risk. Type 2 diabetes is caused by both genetic and environmental factors.
Metrics details. Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes T2D. The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone. Therefore, here we set out to identify and characterize intrinsic properties of myocytes, associated independently with T2D or obesity. This setup enabled us to identify intrinsic properties, originating from muscle precursor cells and retained in the corresponding myocytes.
Adam Kretowski, Francisco J. Obesity and associated diseases are responsible for the global burden of morbidity and mortality, consequently having a huge impact on the economy of healthcare system. Obesity is the leading risk factor for type 2 diabetes T2DM , and both conditions currently affect millions of individuals worldwide, being considered as epidemic. The metabolome is influenced by genetic variants, epigenetic factors, changes in gene expression, or enzyme activity, as well as by environmental factors diet, physical activity, and pharmaceuticals and aging [ 9 ]. Consequently, metabolomics is a valuable tool to study environment-related modifications of the genetic susceptibility.
The discoveries have firmly established more than genomic loci associated with these phenotypes.
You've probably wondered how you developed diabetes. You may worry that your children will develop it, too. Type 1 and type 2 diabetes have different causes, but there are two factors that are important in both. You inherit a predisposition to the disease, then something in your environment triggers it.
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