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Self Eating And Self Killing Crosstalk Between Autophagy And Apoptosis Pdf

self eating and self killing crosstalk between autophagy and apoptosis pdf

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Self-eating and self-killing: crosstalk between autophagy and apoptosis

Important User Information: Remote access to EBSCO's databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use. However, remote access to EBSCO's databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution. Sep, Vol. Author s : Maiuri, M. Abstract: The functional relationship between apoptosis 'self-killing' and autophagy 'self-eating' is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death and suppresses apoptosis , whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell switches between the two responses in a mutually exclusive manner. On a molecular level, this means that the apoptotic and autophagic response machineries share common pathways that either link or polarize the cellular responses.

Self-eating and self-killing: crosstalk between autophagy and apoptosis.

The functional relationship between apoptosis 'self-killing' and autophagy 'self-eating' is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death and suppresses apoptosis , whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell switches between the two responses in a mutually exclusive manner. On a molecular level, this means that the apoptotic and autophagic response machineries share common pathways that either link or polarize the cellular responses. Nature Reviews. Molecular Cell Biology. Maria Chiara Maiuri Guido Kroemer. Get PDF.


The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-.


Role of the Crosstalk between Autophagy and Apoptosis in Cancer

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Autophagy involves degradation of dysfunctional cellular components through the actions of lysosomes. Apoptosis is the process of programmed cell death involving a series of characteristic cell changes. Expert knowledge of autophagy and apoptosis has increased in recent years, particularly in regards to cellular and molecular mechanisms.

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Self-eating and self-killing: crosstalk between autophagy and apoptosis

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of cells within organisms, respectively, and many stress pathways sequentially elicit autophagy, and apoptosis within the same cell. Generally autophagy blocks the induction of apoptosis, and apoptosis-associated caspase activation shuts off the autophagic process. The dialogue between autophagy and cell death pathways influences the normal clearance of dying cells, as well as immune recognition of dead cell antigens. Therefore, the disruption of the relationship between autophagy and apoptosis has important pathophysiological consequences.

The functional relationship between apoptosis 'self-killing' and autophagy 'self-eating' is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death and suppresses apoptosis , whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell switches between the two responses in a mutually exclusive manner. On a molecular level, this means that the apoptotic and autophagic response machineries share common pathways that either link or polarize the cellular responses.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Apoptosis and autophagy constitute the two self-destructive processes by which supernumerary, damaged or aged cells and organelles are eliminated. Beyond this homeostatic function, autophagy is also a process through which cells adapt their metabolisms to starvation, imposed by decreased extracellular nutrients or by decreased intracellular metabolite concentrations that result from growth-factor signalling. The relationship between autophagy and cell death is complex because autophagy constitutes an adaptive response to different kinds of stress by which the cells avoid cell death; yet, in some settings, it can also contribute to the demise of cells.


Maiuri MC, Zalckvar E, Kimchi A, Kroemer GSelf-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8(9).


What is the underlying mechanism of Sertoli cell SC resistance to cell death? High expression of prosurvival B-cell lymphoma-2 BCL2 proteins and inhibition of apoptosis and autophagy prolongs SC survival upon exposure to stress stimuli. In human and in experimental models of orchitis, tolerogenic SC survive stress conditions, while germ cells undergo massive apoptosis. In general, non-dividing highly differentiated cells tend to resist stress conditions for a longer time by favoring activation of prosurvival mechanisms and inhibition of cell death pathways. In this cross sectional study, conditions stimulating apoptosis and autophagy were used to induce cell death in primary rat SC.

Self-eating and self-killing: crosstalk between autophagy and apoptosis.

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